GLI1 upregulates C-JUN through a specific 130-kDa isoform

GLI1 upregulates C-JUN through a specific 130-kDa isoform

The Hedgehog pathway is molecularly linked to increased resistance to cisplatin and increased repair of platinum-DNA damage, through C-JUN. GLI1, which has five known isoforms, is a positive transcriptional regulator in Hedgehog. Southwestern blot assay, EMSA and ChIP assays indicate that only one of five isoforms of GLI1 may be responsible for the Hedgehog link with C-JUN and thus, increased p...

Arsenic Induces Apoptosis through a c-Jun NH

Arsenic has been used as an effective chemotherapy agent for some human cancers, such as acute promyelocytic leukemia. In this study, we found that arsenic induces activation of c-Jun NH2-terminal kinases (JNKs) at a similar dose range for induction of apoptosis in JB6 cells. In addition, we found that arsenic did not induce p53-dependent transactivation. Similarly, there was no difference in a...

Human papillomavirus oncoprotein E6 upregulates c-Met through p53 downregulation.

PURPOSE Human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) carries a distinct clinical behaviour. c-Met oncogene is an important driver for tumour progression and its relationship with HPV in OPSCC was explored in the present study. EXPERIMENTAL DESIGN Knockdown of HPV oncogene E6 or p53 alone and in combination was performed to examine their effects on c-Met ...

Isoform-specific functions of protein kinase C: the platelet paradigm.

Platelets are central to haemostasis and thrombosis. Many key steps in platelet activation and aggregation are regulated by members of the PKC (protein kinase C) family. Multiple isoforms of PKC are expressed in platelets, and evidence is emerging that different isoforms play distinct roles in the platelet activation process. This may, in part, be regulated by isoform-specific interactions betw...

HIP-70: an isoform of phosphoinositol-specific phospholipase C-alpha.